Quinolines and derivatives
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Filtered Search Results
Apexbio Technology LLC Batimastat (BB-94)(Synonyms: BB-94, Batimastat, MMP inhibitor BB-94), 5mg, CAS: 130370-60-4.
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Batimastat (BB-94 CAS 130370-60-4) is a synthetic small-molecule inhibitor targeting matrix metalloproteinases (MMPs) Structurally a polypeptide-like analogue of collagen substrates batimastat contains a peptidic backbone and a hydroxamate moiety that binds the catalytic zinc atom of MMPs It inhibits several MMP subtypes markedly including MMP-1 MMP-2 MMP-3 MMP-7 and MMP-9 with reported IC50 values of 3 4 20 6 and 4 nM respectively In preclinical studies batimastat demonstrates inhibitory effects on tumor growth and angiogenesis across various tumor models including ovarian and colon carcinoma xenografts making it relevant for cancer research and therapeutic development
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eMolecules Ambeed (4-Formyl-phenyl)-carbamicacidtert-butylester 250mg 521412715 A164452 0 000 144072-30-0 MFCD06245541 221 256 C12H15NO3
Ambeed (4-Formyl-phenyl)-carbamicacidtert-butylester 250mg 521412715 A164452 0 000 144072-30-0 MFCD06245541 221 256 C12H15NO3
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Medchemexpress LLC Amino-PEG9-amine | 474082-35-4 | >98% | C20H44N2O9 | 100 MG
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Amino-PEG9-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based linker
- Used in the synthesis of PROTACs
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
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eMolecules EMOLECULES INC
5000491852 7-BROMOISOQUINOLINE 5G
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eMolecules Chem-Impex Sulfo-N-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate sodium salt 50mg 272386939 23033 0 000 92921-24-9 MFCD00054978 436 370 C16H17N2NaO9S
Chem-Impex Sulfo-N-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate sodium salt 50mg 272386939 23033 0 000 92921-24-9 MFCD00054978 436 370 C16H17N2NaO9S
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Medchemexpress LLC Azido-PEG10-amine | 912849-73-1 | 97.0% | C22H46N4O10 | 50 MG
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Azido-PEG10-amine is a PEG-based PROTAC linker used in the synthesis of PROTACs. It is also a click chemistry reagent containing an Azide group, which can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an Azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions
- Can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
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Apexbio Technology LLC Ki16198 355025-13-7 200mg
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Ki16198 (CAS 355025-13-7) is the methyl ester derivative of Ki16425 and functions as an antagonist of lysophosphatidic acid (LPA) receptors preferentially inhibiting LPA1 and LPA3 receptor subtypes Ki16198 reduces receptor-mediated inositol phosphate production with Ki values of 0 34 M (LPA1) and 0 93 M (LPA3) showing minimal inhibition of LPA2 and no significant activity against LPA4 6 In vitro Ki16198 attenuates LPA-induced proliferation migration invasion and proMMP-9 expression in cancer cells In vivo studies report suppression of pancreatic tumor growth metastasis and ascites formation highlighting its utility in investigating LPA-related cancer progression pathways
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Ambeed 2 4DibromoN 4bromophenyl N 2 4
2,4-Dibromo-N-(4-bromophenyl)-N-(2,4-dibromophenyl)aniline, 73087-81-7, 95%
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Medchemexpress LLC m-PEG11-amine | 854601-60-8 | 515.64 g/mol | C23H49NO11 | 100 MG
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m-PEG11-amine is a PEG-based linker bearing a terminal amine used as a cleavable linker in antibody-drug conjugates (ADCs) and as a PROTAC linker or PEG spacer in conjugation chemistry. It provides a water-soluble spacer that facilitates conjugation to activated esters, carboxylic acids, and other reactive groups, improving solubility and flexibility of the resulting bioconjugates.
- PEG-based linker with a terminal primary amine for conjugation
- Used as a cleavable linker in antibody-drug conjugates (ADCs)
- Suitable as a PROTAC linker or PEG spacer in conjugation chemistry
- Water-soluble spacer improves solubility and flexibility of conjugates
- Available in multiple sizes for research-scale synthesis
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Medchemexpress LLC Lodoxamide (U-42585E free acid) | 53882-12-5 | 98.1% | C11H6ClN3O6 | 200 MG
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Lodoxamide (U-42585E free acid) is an antiallergic compound that acts as a mast-cell stabilizer, used for the treatment of asthma and allergic conjunctivitis.
- Inhibits histamine release and calcium influx in mast cells.
- Reduces chemotactic response of eosinophils to fMLP and IL-5.
- Inhibits eosinophil peroxidase release after IgA-dependent activation.
- Demonstrates cromolyn-like activity in mast cell assays and antigen-sensitized rhesus monkeys.
- Inhibits increased respiratory frequency and decreased tidal volume induced by antigen challenge.
- Reduces lung reperfusion injury in organ preservation solutions.
- Improves daytime breathing difficulty, cough, sputum, and sleep in patients.
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Medchemexpress LLC Chlormezanone | 80-77-3 | 99.8% | 200 MG
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Chlormezanone resembles benzodiazepine, and its action is similar to benzodiazepine-type agents. It is used as an anxiolytic and a muscle relaxant.
- Used as an anxiolytic and a muscle relaxant.
- Resembles benzodiazepine and acts similarly to benzodiazepine-type agents.
- Available in solid form (white to off-white).
- For research use only.
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eMolecules EMOLECULES INC
5000491802 4-CHLORO-3-NITROQUINOLINE 25G
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Medchemexpress LLC Quin C1 | 786706-21-6 | 98.5% | 445.51 | 500 UG
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Quin C1 is a highly specific and potent agonist for formyl peptide receptor 2 (FPR2/ALX). It significantly reduces neutrophil and lymphocyte counts in BALF, diminishes expression of TNF-α, IL-1β, KC, and TGF-β1, and decreases collagen deposition in lung tissue.
- Highly specific and potent agonist for formyl peptide receptor 2 (FPR2/ALX)
- Significantly reduces neutrophil and lymphocyte counts in BALF
- Diminishes expression of TNF-α, IL-1β, KC, and TGF-β1
- Decreases collagen deposition in lung tissue
- Potential for research into lung injury
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Medchemexpress LLC LM11A-31 dihydrochloride | 1243259-19-9 | 99.9% | 316.27 | 1 ML
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LM11A-31 dihydrochloride is a non-peptide modulator of p75NTR (neurotrophin receptor p75) and an orally active, potent antagonist of proNGF (nerve growth factor). This amino acid derivative demonstrates high blood-brain barrier permeability, effectively blocking p75-mediated cell death. It has been shown to reverse cholinergic neurite dystrophy in mouse models of Alzheimer's disease at mid- to late-stage progression.
- Non-peptide p75NTR modulator
- Orally active and potent proNGF antagonist
- Amino acid derivative
- High blood-brain barrier permeability
- Blocks p75-mediated cell death
- Reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models
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Medchemexpress LLC 8PPD-Q | 99.9% | 10 MG
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8PPD-Q is a para-phenylenediamine quinone used as a rubber antioxidant with pronounced antioxidant and anti-ozone activity. It is used in environmental pollution and toxicity research because it is toxic to aquatic species, particularly salmonids.
- High purity: 99.88% as reported by the manufacturer.
- Solid form suitable for laboratory handling and storage.
- Molecular formula C20H26N2O2 and molecular weight 326.43 g/mol.
- Available in small pack sizes for analytical work, including 10 mg.
- Store powder at -20 °C (3 years) or 4 °C (2 years); in solvent store at -80 °C (6 months) or -20 °C (1 month).
- Hazardous to aquatic life; suitable for environmental toxicity studies and analytical investigations.
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